Porous glass monoliths with monomodal pore structure are characterized by a high pressure drop in applications where flowing gases and liquids are involved (catalysis, adsorption, chromatography). The integration of defined channels with diameters in the range of µm and mm is a promising way to overcome this limitation. In addition, these channels enable an effective combination of functional glasses with accessory components such as light sources or detectors. The porous glass contains more than 96 wt.-% of SiO2, possesses pore volumes up to 2 cm³/g and a specific surface area up to 500 m²/g. The pores are interconnected and their size is adjustable between 1 to 1000 nm. The material is distinguished by its thermal stability up to 800°C, a high chemical and mechanical stability as well as a good biocompatibility. To add anisotropic micrometer-pores into the porous glass based material, two different methods were applied. For the production of multi-capillaries the down-draw technology was combined with the manufacturing process of porous glass via the VYCOR® route. The synthesis of three-dimensional complex monoliths made of porous glass was realized using the technique of laser sintering in combination with the “classical” production of porous glasses. This work is focused on the specifics of the two methods and the properties of the glass monoliths with anisotropic, hierarchical pore systems.