Exploiting bisphosphonate-bioactive glass interaction for development of bioactive and self-healing composite hydrogelsThursday (29.09.2016) 10:30 - 10:45 Part of:
Hydrogels have been widely recognized as promising candidates for various biomedical applications such as tissue engineering . Bisphosphonates (BP) are a class of drugs commonly used for treatment of osteoporosis and exhibit a strong binding affinity towards hydroxyapatite (HAp) . In this study, we evaluated the binding affinity of a bisphosphonate-functionalized polymer, hyaluronan, towards a bioactive glass (i.e. 45S5 Bioglass) using a colloidal probe Atomic force microscopy (AFM) technique . We then exploited the bisphosphonate-bioglass interaction to develop composite hydrogels and investigated the viscoelastic and self-healing ability of these materials. At last, we evaluated the stability and bioactivity of these hydrogels in simulated body conditions. Through this approach, we were able to produce organic-inorganic composite hydrogels that were injectable, highly self-healing and could lead to a biomimetic mineralization of bone mineral phase on their surface in simulated body conditions. The composite hydrogels developed in this study exhibit a high potential for bone tissue engineering applications.