MSE 2016 - Full Program

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Exploiting bisphosphonate-bioactive glass interaction for development of bioactive and self-healing composite hydrogels

Thursday (29.09.2016)
10:30 - 10:45
Part of:

Hydrogels have been widely recognized as promising candidates for various biomedical applications such as tissue engineering [1]. Bisphosphonates (BP) are a class of drugs commonly used for treatment of osteoporosis and exhibit a strong binding affinity towards hydroxyapatite (HAp) [2]. In this study, we evaluated the binding affinity of a bisphosphonate-functionalized polymer, hyaluronan, towards a bioactive glass (i.e. 45S5 Bioglass) using a colloidal probe Atomic force microscopy (AFM) technique [3]. We then exploited the bisphosphonate-bioglass interaction to develop composite hydrogels and investigated the viscoelastic and self-healing ability of these materials. At last, we evaluated the stability and bioactivity of these hydrogels in simulated body conditions. Through this approach, we were able to produce organic-inorganic composite hydrogels that were injectable, highly self-healing and could lead to a biomimetic mineralization of bone mineral phase on their surface in simulated body conditions. The composite hydrogels developed in this study exhibit a high potential for bone tissue engineering applications.


Mani Diba
Radboud University Medical Center
Additional Authors:
  • Dr. Jie An
    Radboud University Medical Center
  • Prof. Dr. Stephan Schmidt
    Heinrich-Heine-University Düsseldorf
  • Prof. Dr. Aldo Boccaccini
    University of Erlangen-Nuremberg
  • Prof. Dr. Sander Leeuwenburgh
    Radboud University Medical Center